location:Home >Technical support > References

References

Posted by star on 2022-05-24 14:07:05 Hits:23
<<  Back
Xiuzhen Lei ,Wenbin Teng , Ying Fan, Yeke Zhu, Liuxu Yao, Yuhong Li , Shengmei Zhu
From: Plos one
 
Abstract  
The integrity of the intestinal barrier is critical for protecting the host against the pathogen. The role of hypoxia-inducible factor-1α (HIF-1α) in the intestinal barrier disfunction related to sepsis remained unclear. The purpose of the present study is to investigate the role of HIF-1α on oxidative damage, the intestinal mucosal permeability, structural and morphological changes during sepsis. Twenty-four Sprague Dawley (SD) rats were randomly divided into four groups of 6 rats each: the sham group (sham), sepsis group (subjected to cecal ligation and perforation, CLP), sepsis + DMOG group (40 mg/kg of DMOG by intraperitoneal injection for 7 consecutive days before CLP), and sepsis + BAY 87–2243 group (9 mg/kg of BAY 87–2243 orally administered for 3 consecutive days before CLP). Sepsis increased plasma levels of inflammatory mediators, oxidative stress markers and HIF-1α expression; caused pathological damage; increased permeability (P < 0.05); and decreased TJ protein expression in the intestinal mucosa of rats with sepsis (P < 0.05). The addition of DMOG up-regulated HIF-1α, then decreased the plasma levels of inflammatory mediators, oxidative stress markers, alleviated pathological damage to the intestinal mucosa and decreased intestinal permeability (P < 0.05); while BAY 87–2243 treatment had the opposite effects. Our findings showed that HIF-1α protects the intestinal barrier function of septic rats by inhibiting intestinal inflammation and oxidative damage, our results provide a novel insight for developing sepsis treatment.
 
 Download>>
Technical support
FAQs
Catalog/Brochures
Terms and Conditions
References
Address:
Wuhan Abebio Science Co.,Ltd
Room 002,15F-D2,3rd Phase of Software New Park, No.8 Huacheng Avenue, East Lake New-tech Development Zone,Wuhan,China
Phone:+86-27-65523378
Fax:+86-27-65523378
Email: abebio@abebio.com