Reduced Serum FGF17 Levels Are Associated with Deficits in Motivation, Pleasure, and Expression in Antidepressant-Free Patients with Major Depressive Disorder

Fibroblast growth factor 17 (FGF17) is implicated in neurodevelopment and synaptic function, yet its role in motivation remains unclear. This study compared serum FGF17 levels (measured using ELISA) between 74 patients with major depressive disorder (MDD) and 72 healthy controls (HCs), and examined its relationship with negative symptoms measured by the Motivation and Pleasure (MAP) and Expression (EXP) subscales of the Clinical Assessment Interview for Negative Symptoms (CAINS).

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Decoding the spatiotemporal development of the blood-brain barrier in human cortex

The blood-brain barrier (BBB) is essential for maintaining the homeostasis of the central nervous system. However, the processes of BBB formation in humans remain unclear. Here, using single-cell spatiotemporal transcriptomics, we investigate human BBB development from 6 to 21 gestational weeks (GWs) and observe widespread expression of BBB-specific transporters in all brain-endothelial subclusters during development.

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Pyrin Inflammasome Activation Triggers an IL-18-Driven IFNγ Response in Mevalonate Kinase Deficiency

Mevalonate kinase deficiency (MKD) is a rare monogenic autoinflammatory disorder characterized by recurrent fever episodes driven by dysregulated IL-1β secretion. Mutations in the MVK-gene cause enzymatic defects resulting in a shortage of geranylgeranyl pyrophosphate, leading to lowering of the threshold for pyrin inflammasome activation.

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Bulk and single-cell transcriptomics for identification of potential diagnostic biomarkers associated with pulmonary arterial hypertension and integrated stress response and experimental validation

Pulmonary arterial hypertension (PAH) is a lethal vascular disorder characterized by irreversible remodeling of the pulmonary arteries, but the systematic role of the integrated stress response (ISR)-related genes (ISR-RGs) in its pathogenesis remains unexplored.

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PFK-158 enhances colistin efficacy against resistant Edwardsiella piscicida through synergistic mechanisms

Edwardsiella piscicida (E. piscicida) is a well-known bacterial pathogen that causes severe diseases in various cultured fish species, posing a significant threat to the global aquaculture industry.

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Effects study of SCGB2A2 on cell proliferation and milk components biosynthesis in ovine mammary epithelial cells

The Small-Tailed Han (STH) sheep milk has significantly higher fat and protein than DairyMeade (DM) sheep milk. Further study found that the expression of whey protein secretoglobin family 2 A member 2 (SCGB2A2) in STH sheep milk was significantly higher than in DM sheep milk.

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