Akkermansia muciniphila-derived postbiotics reprogram immune balance to combat sepsis via the IDO1/Kyn/AhR metabolic axis

Sepsis is a life-threatening syndrome of organ dysfunction driven by a dysregulated immune response. Effective therapeutic strategies to restore immune homeostasis remain limited. Hypoacylated lipooligosaccharides (ALOS) from Akkermansia muciniphila have emerged as potential immunomodulatory postbiotics, yet their therapeutic potential in sepsis and the underlying mechanisms remain unexplored.

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MAFB Overexpression in Macrophages Promotes Wound Healing in Diabetic Foot Ulcer by Transcriptionally Activating WDR74 to Drive a Tissue-Repair Phenotype and Suppress Inflammation and Oxidative Stress

Diabetic foot ulcer (DFU) represents a significant challenge in clinical management due to its complexity and the impaired wound-healing process associated with diabetes.

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Prenatal cannabis use is associated with altered miRNA and protein expression in the developing human brain

Cannabis is widely used during pregnancy, increasing with cannabis legalization, and has been associated with altered neurodevelopment, yet the precise molecular mechanisms remain poorly understood.

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Chronic exposure to F-53B disrupts sperm quality and steroidogenic regulation in male rats

Chlorinated polyfluoroalkyl ether sulfonic acid (Cl-PFESAs, trade name F-53B), an emerging substitute for perfluorooctane sulfonates (PFOS) used as mist suppressor in electroplating in China, has raised increasing attention due to its environmental persistence, bioaccumulation, and potential health risks.

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Sustainable Valorization of Salmon Head By-Products into Chondroitin Sulfate-Enriched Hydrolysates for Postmenopausal Osteoporosis Management

Postmenopausal osteoporosis is characterized by progressive bone loss and an increased risk of fractures, while current pharmacological approaches mainly suppress bone resorption and present long-term limitations.

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Valorization of Chum Salmon (Oncorhynchus keta) Processing By-Products High-Value Functional Food Ingredients for Skin Health

The strategic recycling of fish processing byproducts as functional materials has attracted increasing attention for sustainable development and human health. In this study, we investigated the dermatological impact of chum salmon (Oncorhynchus keta) byproduct enzyme hydrolysates (OKPE) administered as a dietary supplement in mice.

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