Bulk and single-cell transcriptomics for identification of potential diagnostic biomarkers associated with pulmonary arterial hypertension and integrated stress response and experimental validation

Pulmonary arterial hypertension (PAH) is a lethal vascular disorder characterized by irreversible remodeling of the pulmonary arteries, but the systematic role of the integrated stress response (ISR)-related genes (ISR-RGs) in its pathogenesis remains unexplored.

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PFK-158 enhances colistin efficacy against resistant Edwardsiella piscicida through synergistic mechanisms

Edwardsiella piscicida (E. piscicida) is a well-known bacterial pathogen that causes severe diseases in various cultured fish species, posing a significant threat to the global aquaculture industry.

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Effects study of SCGB2A2 on cell proliferation and milk components biosynthesis in ovine mammary epithelial cells

The Small-Tailed Han (STH) sheep milk has significantly higher fat and protein than DairyMeade (DM) sheep milk. Further study found that the expression of whey protein secretoglobin family 2 A member 2 (SCGB2A2) in STH sheep milk was significantly higher than in DM sheep milk.

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A lateral flow immunoassay strip employing upconversion luminescence for quantitative detection of prostate-specific antigen

A highly sensitive immunochromatographic test strip has been developed based on upconversion nanoparticles (UCNPs) for the quantitative detection of prostate-specific antigen (PSA).

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Therapeutic potential of Ishophloroglucin a from Ishige okamurae in androgenic alopecia: inhibition of 5α-reductase activity and activation of the Wnt/β-catenin signaling pathway in human dermal papilla cells

Androgenic alopecia (AGA) is a common condition of hair loss, triggered by excessive 5α-dihydrotestosterone (5α-DHT) generated via 5α-reductase activity. This study investigated the anti-alopecia effects of Ishophloroglucin A (IPA), a compound isolated from the brown seaweed Ishige okamurae.

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Ganoderma lucidum:polysaccharide ameliorates cancer cachexia with enhanced efficacy in aged group by reprogramming arginine metabolism to modulate Treg formation

Cancer cachexia is a syndrome characterized by profound weight loss, muscle wasting, and metabolic disturbance in cancer patients. Cancer-associated cachexia represents significant biological and clinical challenges that profoundly affect human health. Approximately 20 % of cancer patients succumb directly to cachexia-related complications.

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