Neonatal bone marrow interstitial fluid supports expansion and osteogenic ability of human bone marrow mesenchymal stromal cells

The bone marrow microenvironment is critical for the maintenance and functionality of stem/progenitor cells, which are essential for bone development and regeneration. However, the composition and potential use of bone marrow interstitial fluid have not been well explored.

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Phosphatase and tensin homolog mRNA complexed with hyaluronated lipid nanoparticles for transdermal cancer immunotherapy

The loss of phosphatase and tensin homolog (PTEN) can lead to resistance to immune checkpoint inhibitors (ICIs) in melanoma, thereby promoting immune evasion and tumor progression. These effects can be reversed by restoring PTEN expression, reactivating antitumor immunity, and enhancing therapeutic responses.

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The Effectiveness of Topically Applied Berastagi Orange (Citrus sinensis L.) Peel Extract on Serum C-reactive Protein Levels in Male Rats (Rattus norvegicus) with Incision Wounds

Cutaneous wounds in male rats (Rattus norvegicus) are widely used as models for woundhealing research. C-reactive protein (CRP) is an inflammatory biomarker that increases in response to injury. Berastagi orange peel extract (Citrus sinensis L.) is known for its anti-inflammatory properties; however, its effectiveness in reducing serum CRP levels in cutaneous wounds has not been extensively studied.

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Novel biomarkers of crescentic glomerulonephritis identified by urinary proteomics

Crescentic glomerulonephritis (CrGN) with rapidly progressive renal function loss necessitates prompt pathology diagnosis and treatment. Non-invasive biomarkers are crucial in cases where renal biopsy is unavailable or unsuitable.

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Plastic responses of Plasmodium relictum to competent and non-competent mosquito bites

Environmental unpredictability challenges the transmission success of vector-borne parasites like Plasmodium, whose fitness depends on synchronizing the production of transmission forms, called gametocytes, with vector availability.

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Silver nitrate enhances antibacterial effect of colistin against intrinsic colistin resistant Edwardsiella piscicida

Edwardsiella piscicida (E. piscicida) has been recognized as an important bacterial pathogen affecting fish, and it is also intrinsically resistant to colistin. E. piscicida infects many species of cultured fish and aquatic animals, posing a significant threat to the global aquaculture industry and ecological systems. Therefore, alternative treatment strategies are urgently required to combat E. piscicida infections effectively.

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