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Recombinant Human Galanin prepropeptide (GAL) Protein


Species Reactivity

Human

Source

Prokaryotic expression

Host

E. coli

Synonyms

GAL; GAL-GMAP; GALN; GLNN; GMAP

Concentration

1 mg/mL

Form

Lyophilized or Liquid

Purity

> 90% as determined by SDS-PAGE

Residues

Ala20~Ser123 (P22466)

Tag

N-terminal His-tag

Purification

Affinity purification

Molecular Weight(MW)

12 kDa

Applications

Western blotting,ELISA;SDS-PAGE;Antigen;

Cat

AP50213HU

Size

100μg 500μg 1mg

Price

Inquire

Availability

3-5 working days

Manual

Inquire
Product Overview:
Galanin is a neuropeptide encoded by the GAL gene, that is widely expressed in the brain, spinal cord, and gut of humans as well as other mammals. Galanin signaling occurs through three G protein-coupled receptors. The functional role of galanin remains largely unknown; however, galanin is predominately involved in the modulation and inhibition of action potentials in neurons. Galanin has been implicated in many biologically diverse functions, including: nociception, waking and sleep regulation, cognition, feeding, regulation of mood, regulation of blood pressure, it also has roles in development as well as acting as a trophic factor. Galanin neurons in the medial preoptic area of the hypothalamus may govern parental behaviour. Galanin is linked to a number of diseases including Alzheimer's disease, epilepsy as well as depression, eating disorders and cancer. Galanin appears to have neuroprotective activity as its biosynthesis is increased 2-10 fold upon axotomy in the peripheral nervous system as well as when seizure activity occurs in the brain. It may also promote neurogenesis.
Usage:
Reconstitute in PBS or others.
Stability:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage:
Store it under sterile conditions at -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -80℃.
Stroage Buffer:
Lyophilized from 20 mM PB, 300 mM NaCl,pH 7.4
Precautions:
This product is for research use only, not for diagnostic or therapeutic use.