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Recombinant Human Pepsinogen II (PGII) Protein


Species Reactivity

Human

Source

Prokaryotic expression

Host

E. coli

Synonyms

PGII

Concentration

1 mg/mL

Form

Lyophilized or Liquid

Purity

> 95% as determined by SDS-PAGE

Residues

N/A

Tag

N/A

Purification

Affinity purification

Molecular Weight(MW)

N/A

Applications

Western blotting,ELISA;SDS-PAGE;Antigen;

Cat

AP50020HU

Size

100μg 500μg 1mg

Price

Inquire

Availability

3-5 working days

Manual

Inquire
Product Overview:
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis
Usage:
Reconstitute in PBS or others.
Stability:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage:
Store it under sterile conditions at -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -80℃.
Stroage Buffer:
Lyophilized from sterile 20mM PB,240mM NaCl,PH6.16.
Precautions:
This product is for research use only, not for diagnostic or therapeutic use.