Introduction: Cutaneous wounds in male rats (Rattus norvegicus) are widely used as models for woundhealing research. C-reactive protein (CRP) is an inflammatory biomarker that increases in response to injury. Berastagi orange peel extract (Citrus sinensis L.) is known for its anti-inflammatory properties; however, its effectiveness in reducing serum CRP levels in cutaneous wounds has not been extensively studied.

Objective: This study aimed to evaluate the effectiveness of topically administered Berastagi orange peel extract on serum CRP levels in male rats with cutaneous wounds.

Methods: A total of 25 male rats were divided into three groups: control, treatment with orange peel extract, and treatment with a standard ointment. Wounds were inflicted on the rats backs, and treatments were administered for a few days. Serum CRP levels were measured using the ELISA method.

Results: Results indicated that the group receiving Berastagi orange peel extract exhibited a significant reduction in CRP levels compared to the control group (p < 0.05). The standard ointment group also showed a reduction, but not as effectively as the orange peel extract.

Conclusion: Berastagi orange peel extract significantly reduces serum C-reactive protein levels in male rats with cutaneous wounds. These findings support the use of natural extracts as alternatives in wound healing therapy.

Keywords: Orange Peel Extract, C-Reactive Protein, Wound Healing, Male Rats.