Rabbit Anti-Human Dok-2 Polyclonal Antibody

Docking protein 2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.The DOK2 cDNA clone encodes a 412-amino acid protein with a molecular mass of 53 to 56 kD. The DOK2 protein has a potential pleckstrin homology (PH) domain at the N terminus, 13 potential tyrosine phosphorylation sites, 6 PXXP motifs, and 2 YXXPXD motifs (predicted Ras-GAP SH2 domain binding sites). It shares 34.8% overall amino acid identity with another tyrosine-phosphorylated protein, p62dok (DOK1), which also contains a predicted PH domain at its N terminus.

Store at -20°C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-8°C.

Shipped at 2-8°C, Store it under sterile conditions at -20°C to -80°C upon receiving. **Avoid repeated freeze-thaw cycles.**