Effects of HIF-1α agonist or inhibitor on intestinal mucosal permeability in rats with sepsis

Objective To investigate the effects of sepsis and HIF-1α agonist or inhibitor on intestinal mucosal barrier function.Methods SD rats were randomly divided into sham operation group (sham), Sepsis group treating with cecal ligation and perforation (CLP), Sepsis+HIF-1α agonist group (sepsis + DMOG) receiving intraperitoneal injection of HIF-1α agonist DMOG (40 mg/kg) for 7 consecutive days before CLP, Sepsis+HIF-1α inhibitor group (sepsis+BAY87-2243) orally administered with HIF-1α inhibitor BAY87-2243 (9 mg/kg) for 3 consecutive days before CLP.

Product: Rat D-lactic acid ELISA Kit

Pub Date：2021-10-27   IF: 0.552

Serum Mitochondrial Quality Control Related Biomarker Levels are Associated with Organ Dysfunction in Septic Patients

To investigate the feasibility and the value of using mitochondrial quality control (MQC)-related proteins as biomarkers in septic patients.The enrolled subjects were divided into four groups: healthy control group (n = 30), intensive care unit (ICU) control group (n = 62), septic nonshock group (n = 40), and septic shock group (n = 94). Serum levels of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), fission protein 1 (Fis1), mitofusin2 (Mfn2), and Parkin were measured by enzyme-linked immunosorbent assay at the time of enrollment for all groups. Clinical parameters and laboratory test results were also collected.

Product: Human Mitochondrial fission 1 protein (FIS1) ELISA Kit  Human Mitofusin-2 (MFN2) ELISA Kit 

Pub Date：2021-09-01   IF: 3.454

Comprehensive Analysis of DOK Family Genes Expression, Immune Characteristics, and Drug Sensitivity in Human Tumors

DOK is a new type of regulatory protein family that participates in the regulation of tumor cell growth. However, most of the studies are conducted in cell lines, and systematic studies have not been conducted in human tumors.

Product: Rabbit Anti-Human Dok-1 Polyclonal Antibody  Rabbit Anti-Human Dok-2 Polyclonal Antibody  Rabbit Anti-Human Dok-4 Polyclonal Antibody  Rabbit Anti-Human Dok-6 Polyclonal Antibody 

Pub Date：2021-06-12   IF: 6.992

L-Carnitine Ameliorates the Muscle Wasting of Cancer Cachexia through the AKT/FOXO3a/MaFbx Axis

Recent studies suggest potential benefits of applying L-carnitine in the treatment of cancer cachexia, but the precise mechanisms remain unknown. This study was conducted to determine the mechanism by which L-carnitine reduces cancer cachexia.

Product: Mouse Interleukin-1 beta (IL1B) ELISA Kit  Mouse Interleukin 6 (IL-6) ELISA Kit  Mouse Tumor necrosis factor α (TNF-α) ELISA Kit 

Pub Date：2021-06-02   IF: 3.211

Prognostic Significance of the Fission1/Parkin Ratio for Sepsis: A Prospective Cohort Study

Fission1 (Fis1) and parkin are key proteins related to mitochondrial fission and mitophagy, respectively. This study aimed to assess the prognostic value of the Fis1/parkin ratio as a biomarker in patients with sepsis.

Product: Human Mitofusin-2 (MFN2) ELISA Kit

Pub Date：2021-05-13   IF: 3.900

TIGAR mitigates atherosclerosis by promoting cholesterol efflux from macrophages

TP53-induced glycolysis and apoptosis regulator (TIGAR) is now characterized as a fructose-2,6-bisphosphatase to reduce glycolysis and protect against oxidative stress. Recent studies have demonstrated that TIGAR is associated with cardiovascular disease.

Product: Human 27-hydroxycholesterol ELISA Kit

Pub Date：2021-04-14   IF: 3.919