Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing

The deposition of β-amyloid (Aβ) in the brain plays a major role in the pathogenesis of Alzheimer’s disease (AD). Aβ is generated via amyloid precursor protein (APP) cleavage through the amyloidogenic pathway.

Product: Human Krueppel-like factor 5 (KLF5) ELISA Kit

Pub Date：2022-07-26   IF: 6.420

The protective effects of HIF-1α activation on sepsis induced intestinal mucosal barrier injury in rats model of sepsis

The integrity of the intestinal barrier is critical for protecting the host against the pathogen. The role of hypoxia-inducible factor-1α (HIF-1α) in the intestinal barrier disfunction related to sepsis remained unclear.

Product: Rat D-lactic acid ELISA Kit

Pub Date：2022-05-16   IF: 3.240

Higher Serum RCAN2 Levels Are Associated with Metabolically Unhealthy Individuals, Either with Obesity or Not

Regulator of calcineurin 2 (RCAN2) has been documented to cause weight gain and related pathology and metabolism abnormalities in animal researches. The aim of the study was to compare serum RCAN2 concentrations in metabolically healthy (MH) and metabolically unhealthy (MUH) individuals.

Product: Human Calcipressin-2 (RCAN2) ELISA Kit

Pub Date：2022-04-21

Xuedan Sustained Release Pellets Ameliorate Dextran Sulfate Sodium–Induced Ulcerative Colitis in Rats by Targeting Gut Microbiota and MAPK Signaling Pathways

Cucurbitacins have a variety of bioactivities, such as anticancer, anti-inflammatory, antidepressant-like, and antiviral effects, but their pharmacological effect in ulcerative colitis (UC) has not been reported until now.

Product: Rat Interleukin-1 beta (IL1B) ELISA Kit  Rat Tumor necrosis factor α (TNF-α) ELISA Kit  Rat Interleukin 6 (IL-6) ELISA Kit  Rat Interleukin 10 (IL-10) ELISA Kit  Rat Nitric oxide (NO) ELISA Kit  Rat Myeloperoxidase (MPO) ELISA Kit 

Pub Date：2022-04-20   IF: 5.810

Effect of dexmedetomidine up-regulating HIF-1ɑ on intestinal mucosal barrier injury related to sepsis in rats

Dexmedetomidine (DEX), a highly selective α2 receptor agonist. DEX can inhibit the release of inflammatory factors in septic rats.

Product: Rat D-lactic acid ELISA Kit

Pub Date：2022-03-29

Elevated Serum Regulator of Calcineurin 2 is Associated With an Increased Risk of Non-Alcoholic Fatty Liver Disease

The promoting effect of the regulator of calcineurin 2 (RCAN2) in hepatic steatosis has been observed in animal studies. However, the association of RCAN2 with non-alcoholic fatty liver disease (NAFLD) in humans remains unclear.

Product: Human Calcipressin-2 (RCAN2) ELISA Kit  Mouse Calcipressin-2 (RCAN2) ELISA Kit 

Pub Date：2022-03-16   IF: 5.810