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Increasing Inhaled Steroids Curbs Asthma in Adults

For adults and adolescents with asthma being treated with inhaled glucocorticoids, with or without add-on therapy, the temporary quadrupling of the dose at the first sign of asthma control deterioration reduces the incidence of severe exacerbations by 19%, according to results from a new study.


Beer compound decreases weight gain and lowers cholesterol

Metabolic syndrome is a health condition affecting about 34% of adults in the US, putting them at risk for cardiovascular disease, diabetes, stroke and other diseases. Now, researchers from Oregon State University say a flavonoid found in hops and beer could reduce weight gain and improve markers of metabolic syndrome.


C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

Recently, Aaron Burberry from Harvard University and his team published their research about 9orf72 suppresses systemic and neural inflammation induced by gut bacteria on Nature.


HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression

Liver dysfunction is strongly associated with poor survival of sepsis patients. Cytosolic lipopolysaccharide (LPS) sensing by Caspase-4/5/11 for pyroptosis activation is a major driver of the development of sepsis.


Poly (I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice

Polyclonal anti-D (RhIg) therapy has mitigated hemolytic disease of the newborn over the past half century, though breakthrough anti-D alloimmunization still occurs in some treated females.


Guselkumab in biologic-naive patients with active psoriatic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial

Guselkumab, a human monoclonal antibody that specifically inhibits IL-23 by binding the cytokines p19 subunit, was efficacious and demonstrated an acceptable benefit–risk profile in patients with active psoriatic arthritis who were naive to treatment with biologics.


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