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Metastasis: Regressing to self-renewal

The epithelial–mesenchymal transition (EMT) is a developmental process that appears to be adopted by tumour cells to confer malignant traits such as invasiveness, survival and motility. However, how malignant cells that have undergone an EMT are able to propagate tumour growth at distant sites has remained unclear.

Date:2019-03-20

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice

Recently scientists from Wake Forest School of Medicine, Winston-Salem, North Carolina, USA reported their investigation of “Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice” on The Journal of Clinical Investigation.

Date:2019-03-05

Cell kinetics in the adult neurogenic niche and impact of diet-induced accelerated aging

Neurogenesis in adult brain, a powerful mechanism for neuronal plasticity and brain repair, is altered by aging and pathological conditions, including metabolic disorders. The search for mechanisms and therapeutic solutions to alter neurogenesis requires understanding of cell kinetics within neurogenic niches using a high throughput quantitative approach.

Date:2019-03-05

Scientists devise strategies to counteract T cell exhaustion in CAR T cancer therapies

A growing number of cancer patients are being offered a promising new treatment called CAR T cell therapy. In this therapy, a patients own T cells are removed and genetically engineered to better recognize cancer cells. The cells are then returned to the patients body, where they mount an immune response to destroy the cancer.

Date:2019-03-05

Researchers link mutations in antibodies to heightened risk of allergic diseases in children

A team of researchers from Stanford University, the University of Cincinnati, Childrens Hospital Medical Center and the Garvan Institute of Medical Research has found a link between mutated antibodies and a heightened risk of allergic diseases in children. In their paper published in the journal Science Translational Medicine, the researchers describe their multi-year study involving young children volunteers, and what they found.

Date:2019-02-28

Adiponectin gene associated with breast cancer risk

Cancer experts at Northwest Memorial Hospital recently reported that they found that the adiponectin gene mutation is likely to increase the risk of breast cancer in women, and it will become the third gene associated with breast cancer.

Date:2019-02-15

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