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Scientists pinpoint potential new target for regulating inflammation

Scientists from Trinity College Dublin have discovered a potential new target for regulating inflammation, which drives a range of diseases including diabetes, cancer and Alzheimers. The potential target is an ancient immune protein SARM that has been conserved throughout evolution and thus is very similar in humans, other mammals, flies and worms.

Date:2019-05-08

Study reveals reasons for different responses to anti-PD-1 checkpoint blockade immunotherapy

A team of researchers affiliated with Johns Hopkins University and Memorial Sloan Kettering Cancer Center has found some of the reasons for different responses to anti-PD-1 checkpoint blockade immunotherapy in cancer patients.

Date:2019-05-08

PLOS ONE:Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1

On Apr 11,2019, scientists from Southern Methodist University and National Institutes of Health, Bethesda, MD released their study on Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1 in PLOS ONE.

Date:2019-05-06

Neurology:Inflammatory cytokines and ischemic stroke risk

Scientists from University of Vermont Larner College of Medicine, Burlington released their study on Inflammatory cytokines and ischemic stroke risk on April 19, 2019 in Neurology.They studied circulating interleukin IL-6, IL-8, and IL-10 concentrations and incident ischemic stroke risk in a biracial cohort, and determined if these cytokines mediated the racial disparity in stroke incidence affecting the black population.

Date:2019-05-06

Science: Revealing the Devil Behind the Death Killer

A new study has found that interleukin-3 (IL-3), an inflammatory factor closely associated with anaphylaxis, seems to play an important role in life-threatening immune response sepsis.In the March 13 issue of Science, researchers from the Massachusetts General Hospital (MGH) described their findings that the presence of IL-3 in a septic mouse model is a necessary condition for sepsis.

Date:2019-05-06

Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells

Chronic myeloid leukemia (CML) originates in a hematopoietic stem cell (HSC) transformed by the breakpoint cluster region (BCR)-abelson (ABL) oncogene and is effectively treated with tyrosine kinase inhibitors (TKIs).

Date:2019-04-03

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