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Hereditary cancer variants and homologous recombination deficiency in biliary tract cancer

Although associations between biliary tract cancer and BRCA germline variants have been reported, homologous recombination deficiency has not been investigated in BTCs.

Date：2022-10-31

Association of Obesity With Cognitive Decline

There are disparities in the prevalence of obesity by race and the relationship between obesity and cognitive decline is unclear.

Date：2022-10-31

MRG15 aggravates non-alcoholic steaohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM

The mortality factor 4-like protein 1 (MORF4L1, also called MRG15) was previously identified as a master nuclear chromatin remodeler in the rhythmic regulation of lipid synthesis gene expression in liver. Whether it also contributes to the progression from liver steatosis to NASH is unclear.

Date：2022-09-08

Characteristics Associated With Growth Differentiation Factor 15 in Heart Failure With Preserved Ejection Fraction and the Impact of Pirfenidone

Growth differentiation factor 15 is elevated in heart failure with preserved ejection fraction and is associated with adverse outcome, but its relationship with myocardial fibrosis and other characteristics remains unclear.

Date：2022-09-08

Researchers report encouraging immunotherapy option for relapsed myeloma patients

Mount Sinai researchers have published results that show encouraging therapeutic options for patients with the blood cancer multiple myeloma after first-line treatment with bispecific antibodies fails.

Date：2022-09-08

Researchers identify possible treatment target for a type of sporadic ALS

Researchers have published two papers describing how they identified a potential new pathway for treating a sporadic form of amyotrophic lateral sclerosis (ALS).

Date：2022-09-08

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