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Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance

Increased levels of circulating low-density lipoprotein cholesterol (LDLc) are tightly linked to the development of cardiovascular disease (CVD).

Date:2022-04-29

Vigilance against vitamin B7 interference in laboratory testing

Biotin, also known as vitamin B7, is a frequent visitor in various nutritional supplements and health foods. However, in recent years, the interference of biotin to laboratory detection has been repeatedly emphasized and mentioned.

Date:2022-04-29

The antibodies of ´post-treatment HIV controllers′

A very small percentage of people with HIV-1, known as "post-treatment controllers" (PTCs), are able to control their infection after interrupting all antiretroviral therapy.

Date:2022-04-24

Study reveals male sex hormones are new targets for cancer immunotherapy

Patients with cancers stemming from non-reproductive organs, such as bladder and liver cancer, have striking discrepancies in incidence, progression, response to treatment and survival outcomes depending on their sex. In almost all cases, male patients have worse prognoses and outcomes.

Date:2022-04-24

Glitchy protein production may hasten aging

Cells are continually cranking out new proteins, but like car factories, they produce some lemons. A study of mice now suggests these defective proteins speed aging, bolstering an idea first proposed 60 years ago.

Date:2022-04-24

Endothelial Unc5B controls blood-brain barrier integrity

The BBB protects the brain from toxins and pathogens and maintains homeostasis and proper function of the CNS1,2. To form the BBB, endothelial cells (ECs) lining brain blood vessels acquire a series of features that control the movement of ions, molecules and cells between the blood and the brain3.

Date:2022-04-24

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