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MRG15 aggravates non-alcoholic steaohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM

The mortality factor 4-like protein 1 (MORF4L1, also called MRG15) was previously identified as a master nuclear chromatin remodeler in the rhythmic regulation of lipid synthesis gene expression in liver. Whether it also contributes to the progression from liver steatosis to NASH is unclear.


Characteristics Associated With Growth Differentiation Factor 15 in Heart Failure With Preserved Ejection Fraction and the Impact of Pirfenidone

Growth differentiation factor 15 is elevated in heart failure with preserved ejection fraction and is associated with adverse outcome, but its relationship with myocardial fibrosis and other characteristics remains unclear.


Researchers report encouraging immunotherapy option for relapsed myeloma patients

Mount Sinai researchers have published results that show encouraging therapeutic options for patients with the blood cancer multiple myeloma after first-line treatment with bispecific antibodies fails.


Researchers identify possible treatment target for a type of sporadic ALS

Researchers have published two papers describing how they identified a potential new pathway for treating a sporadic form of amyotrophic lateral sclerosis (ALS).


Summary of hepatitis B virus (HBV) markers

Hepatitis B virus (HBV) infection is a worldwide epidemic. It is reported that there are about 296 million chronic HBV infected people in the world, and about 1 million people die of HBV infection related diseases every year.


Six application experiences of sglt-2 inhibitors "escort" patients with heart failure

Sodium glucose cotransporter 2 (sglt-2) inhibitors help prevent heart failure in high-risk patients and slow down the progression of heart failure.


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