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Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

E. Antonio Chiocca, scientists from Harvard Medical School and his teams research about interleukin-12 gene therapy in patients was published recently on Science Translational Medcines. The antitumor cytokine interleukin-12 cannot be used as a systemic treatment because of excessive toxicity.


Can a DNA construction kit replace expensive antibody medication?

Researchers at KU Leuven in Belgium have developed a technique to make sheep produce new antibodies simply by injecting the DNA building blocks. This approach is much cheaper and more efficient than producing antibodies industrially and administering them afterwards.


A liquid biopsy test can identify patients who may respond to immune checkpoint blockade

A new liquid biopsy test could detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating that it could help determine which patients are likely to respond to immune checkpoint inhibitors, according to results published in Clinical Cancer Research, a journal of the American Association for Cancer Research.


Clues To Development Of The Pancreas Provided By Rare Genetic Disorder Could Lead To Diabetes Therapy

A rare genetic disorder has given researchers at the University of Exeter a surprising insight into how the pancreas develops. The finding provides a clue to how it may be possible to programme stem cells - master cells in the body that can develop into specialised cells - to become pancreatic cells.


TNF-alpha driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

Aging and chronic inflammation are independent risk factors for the development of atherothrombosis and cardiovascular disease.


Prospective isolation of non-hematopoietic cells of the niche and their differential molecular interactions with HSCs

A major limitation preventing in vivo modulation of hematopoietic stem cells (HSCs) is the incomplete understanding of the cellular and molecular support of the microenvironment in regulating HSC fate decisions.


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