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Scientists describe how protein acts as courier in cell signaling pathways

Normal development, from fertilized egg to adult organism, depends on each cell receiving proper instructions from its environment. In response to such incoming information, receptors on a cells surface send signals to the nucleus that tweak gene expression and control cellular function.


TNF inhibitor failed to improve severe hand osteoarthritis

WASHINGTON, DC - Adalimumab, a tumor necrosis factor (TNF) inhibitor commonly used to treat rheumatoid arthritis (RA), failed to improve severe hand osteoarthritis (OA) in a randomized, double-blind, placebo-controlled trial, researchers reported at here ACR.


Disease Mutations And The Parkin Protein

Researchers at the MRC Laboratory of Molecular Biology in the United Kingdom have determined the crystal structure of Parkin, a protein found in cells that when mutated can lead to a hereditary form of Parkinsons disease.


Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism

Growth differentiation factor 15 (GDF-15), a marker of inflammation and oxidative stress, has emerged as a biomarker for arterial cardiovascular disease.


Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis

Mastocytosis is a hematopoietic neoplasm characterized by expansion of KIT D816V-mutated clonal mast cells in various organs and severe or even life-threatening anaphylactic reactions.


Researchers identify RNA molecule that helps lung cancer cells evade immune system

Researchers in Spain have identified a non-coding RNA molecule that helps lung cancer cells proliferate and avoid being killed by the bodys immune cells.


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