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Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells

Chronic myeloid leukemia (CML) originates in a hematopoietic stem cell (HSC) transformed by the breakpoint cluster region (BCR)-abelson (ABL) oncogene and is effectively treated with tyrosine kinase inhibitors (TKIs).


Chemosensory modulation of neural circuits for sodium appetite

Sodium is the main cation in the extracellular fluid and it regulates various physiological functions. Depletion of sodium in the body increases the hedonic value of sodium taste, which drives animals towards sodium consumption.


Research reveals how immune cells help tumors escape body´s defenses

New research from the University of Pittsburgh School of Medicine and the UPMC Hillman Cancer Center sheds light on how tumors use the bodys regulators of immunity for their own benefit. Published today in Nature Immunology, the findings could be used to develop the next generation of immune therapies to fight various cancers.


New research shows 73 percent of allergists prescribe under-the-tongue allergy tablets

Allergy shots (subcutaneous immunotherapy or SCIT) have been available for more than 100 years. Allergy tablets (sublingual immunotherapy or SLIT) have been approved by the Food and Drug Administration (FDA) for use in the United States for four years.


Progesterone supplements do not help women with recurrent miscarriages

progesterone is a sex hormone that issential for the maintenance of pregnancy. However, taking progesterone supplements during the first 12 weeks of pregnancy does little to help women with a history of unexplained, recurrent miscarriages.


Metastasis: Regressing to self-renewal

The epithelial–mesenchymal transition (EMT) is a developmental process that appears to be adopted by tumour cells to confer malignant traits such as invasiveness, survival and motility. However, how malignant cells that have undergone an EMT are able to propagate tumour growth at distant sites has remained unclear.


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