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Germline AGO2 mutations impair RNA interference and human neurological development
RNA interference is a major mechanism for post-transcriptional regulation of gene expression. Precursors of microRNAs (miRNAs) are transcribed, processed into mature miRNAs and loaded onto Argonaute (AGO1-4) proteins to form the RNA-induced silencing complex (RISC).
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27
Nov,2020
Research reveals how a fungal infection activates inflammation
Scientists at St. Jude Childrens Research Hospital have identified the mechanisms behind inflammasome activation driven by infection with the fungal pathogen Aspergillus fumigatus. Fungal infection, especially with A. fumigatus, is a leading cause of infection-associated deaths in people with compromised immune systems.
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27
Nov,2020
VAV1 mutations contribute to development of T-cell neoplasms in mice
Activating mutations in the Vav guanine nucleotide exchange factor 1 (VAV1) gene are reported in various subtypes of mature T-cell neoplasms (TCN). However, oncogenic activities associated with VAV1 mutations in TCN remain unclear.
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21
Oct,2020
SPATS2, negatively regulated by miR-145-5p, promotes hepatocellular carcinoma progression through regulating cell cycle
Hepatocellular carcinoma (HCC) is the sixth most common neoplasm and the third leading cause of cancer-related deaths worldwide. Although great progress has been made in treatment strategies, such as surgical resection, trans-arterial chemoembolization, radiofrequency ablation, and liver transplantation, the five-year survival rate of HCC is less than 10%.
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21
Oct,2020
Inherited mutation located in part of the KRAS gene leads to abnormal endometrial growth and endometrial risk
Published in the Feb. 3 early online issue of EMBO Molecular Medicine, the study explored an inherited mutation located in part of the KRAS gene, which leads to abnormal endometrial growth and endometrial risk.
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16
Oct,2020
A small U.S. study suggests daily hormone injections may boost mental agility in older people with and without mild cognitive problems
People who got growth hormone-releasing hormone (GHRH), as opposed to inactive injections, improved on tests of attention and concentration skills - what psychologists call executive function.
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16
Oct,2020
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