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Your body clock determines your weight

Recently, a discovery from the Garvan Institute of medical research in Australia revealed that an important signal system in the brain controls appetite, energy consumption and body fat composition. One of the specific genes determines the bodys weight.


The largest trial of patients with EGFR mutation-positive NSCLC

RIDGEFIELD, Conn., June 4, 2012 /PRNewswire/ -- Boehringer Ingelheim Pharmaceuticals, Inc. today announced that the companys pivotal Phase III clinical trial, LUX-Lung 3, investigating afatinib as a first-line treatment in patients with stage IIIb or IV non-small cell lung cancer (NSCLC) harboring an epidermal growth factor receptor (EGFR) mutation, met its primary endpoint of progression-free survival (PFS).


Germline AGO2 mutations impair RNA interference and human neurological development

RNA interference is a major mechanism for post-transcriptional regulation of gene expression. Precursors of microRNAs (miRNAs) are transcribed, processed into mature miRNAs and loaded onto Argonaute (AGO1-4) proteins to form the RNA-induced silencing complex (RISC).


Research reveals how a fungal infection activates inflammation

Scientists at St. Jude Childrens Research Hospital have identified the mechanisms behind inflammasome activation driven by infection with the fungal pathogen Aspergillus fumigatus. Fungal infection, especially with A. fumigatus, is a leading cause of infection-associated deaths in people with compromised immune systems.


VAV1 mutations contribute to development of T-cell neoplasms in mice

Activating mutations in the Vav guanine nucleotide exchange factor 1 (VAV1) gene are reported in various subtypes of mature T-cell neoplasms (TCN). However, oncogenic activities associated with VAV1 mutations in TCN remain unclear.


SPATS2, negatively regulated by miR-145-5p, promotes hepatocellular carcinoma progression through regulating cell cycle

Hepatocellular carcinoma (HCC) is the sixth most common neoplasm and the third leading cause of cancer-related deaths worldwide. Although great progress has been made in treatment strategies, such as surgical resection, trans-arterial chemoembolization, radiofrequency ablation, and liver transplantation, the five-year survival rate of HCC is less than 10%.


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