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Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome

Selective serotonin reuptake inhibitors (SSRIs) have a well-established association with bleeding complications and conflicting reports on outcome after stroke.


Nasal biomarkers predict severity of pollen-specific allergy symptoms

For people with allergies, contact with pollen leads to symptoms such as sneezing, rhinitis and watery eyes. This may sound trivial, but is in fact a complex correlation of physiological processes. As these have not yet been fully understood, we do not know exactly yet how allergies develop and how the symptoms are triggered.


Immune-regulating drug improves gum disease in mice

Periodontal disease, also known as gum disease, is a common problem in older adults that causes painful inflammation, bone loss and changes in the good bacteria that live in the mouth. Yet there are no treatments available beyond tooth removal and/or having good oral hygiene.


Protease Activity in Single-Chain Prekallikrein

Plasma prekallikrein, the precursor of the enzyme kallikrein, has intrinsic proteolytic activity. Prekallikrein activity may contribute to bradykinin production and to initiation of contact activation when blood is exposed surfaces.


Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions

They found that NS-causing SHP2 gain-of-function mutation induces a signaling defect–related thrombopathy with an increased bleeding risk, while NSML-causing SHP2 loss of function induces an elevated platelet response to collagen at high shear rate.


Researchers determine how a specific protein regulates tumor growth

Immune checkpoints are surface proteins that cancer cells use to evade immune response. These surface proteins are critical for cancer cell growth and drugs targeting these proteins have revolutionized the management of patients with a wide array of cancers.


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