Isoflavones inhibit tumor metastasis without affecting healthy cells. An international team of scientists found that soybean molasses and pueraria contain isoflavones with high antioxidant and cytotoxic activities. This means they can help fight cancer, especially when chemotherapy or surgical removal of metastases may be dangerous. The study was described in the journal plants. Isoflavones in soybean molasses and pueraria lobata are phytoestrogens that mimic the role of human estrogen. They help bind and remove free radicals from the body, which can cause cell damage and destroy the function of the immune system. This in turn can lead to various diseases, including cancer and tumor formation.
Isoflavones found in plants are effective in affecting the dense tumor structure of human internal organs. For example, soybean extract is most effective against metastasis and malignant tumor cells in muscle (rhabdomyosarcoma), while isoflavones in pueraria root show good anticancer effects against brain cancer (glioblastoma multiforme) and bone and connective tissue cancer (osteosarcoma). The cell lines of these diseases were studied in vitro.
"The cancers studied have a high degree of metastasis and are resistant to treatment regimens. They are particularly dangerous for children: about 40% of childhood cancers come from these types of cancers. Chemotherapy and radiotherapy only work in 50% of cases, the remaining 50% of cancer cells continue to metastasize, and cancer cells in children grow faster than adults. In addition, radiotherapy is very toxic, especially for children. Therefore, it is necessary to develop innovative strategies Slightly, it inhibits the growth of tumor cells without side effects, so plant extracts are an alternative to traditional drug treatment, "explained saied abushanab, a research engineer in the organic synthesis laboratory of Ural Federal University (urfu).
The scientists determined that the most active isoflavones in the two plant extracts are daidzein and genistein, which can protect bone tissue. Puerarin, formononetin and chickpea a were also found. Scientists used a "green solvent" called natural hypoeutectic solvents (nades) to extract isoflavones. The study used a solution of choline chloride and citric acid, an organic compound that is non-toxic to the body.
"This technology has been shown to extract isoflavones more effectively than synthetic methods. It should be noted that choline chloride and citric acid also have their own therapeutic properties, so they can enhance the effect of isoflavones on cancer cells," abushanab explained.
The phytoestrogens extracted from two plant preparations were identified by HPLC-MS and quantified by UV detector. The scientists point out that the combination of these methods makes it possible to qualitatively determine the compounds in the extract and determine the amount of these substances in the study sample.
Previously, scientists found that isoflavones in kudzu flower and root, red clover flower and soybean molasses were effective in the treatment of acute respiratory distress syndrome.
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