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Microengineered Multi-Organoid System from hiPSCs to Recapitulate Human Liver-Islet Axis in Normal and Type 2 Diabetes

Type 2 diabetes mellitus (T2DM) is a systematic multi-organ metabolic disease, which is characterized by the dynamic interplay among different organs.The increasing incidence of T2DM reflects an urgent need for the development of in vitro human-relevant models for disease study and drug therapy.

Product: Human Albumin (ALB) ELISA Kit  Human Insulin (INS) ELISA Kit 

Pub Date:2021-12-23   IF: 16.806

Preventive Effect of Anemarrhenae rhizome and Phellodendri cortex on Danazol-Induced in Precocious Puberty in Female Rats and Network Pharmacological Analysis of Active Compounds

Anemarrhenae rhizome and Phellodendri cortex have historically been used for the treatment of precocious puberty (PP) in oriental medicine.Our study aimed to evaluate the effect of APE, a mixture of the extracts from these herbs, against danazol-induced PP in female rats.

Product: Rat Estradiol (E2) ELISA Kit  Rat Luteinizing hormone (LH) ELISA Kit  Rat Follicle-stimulating hormone (FSH) ELISA Kit  Rat Alkaline phosphatase (ALP) ELISA Kit 

Pub Date:2021-12-22   IF: 3.935

Athrixia phylicoides tea infusion (bushman tea) improves adipokine balance, glucose homeostasis and lipid parameters in a diet-induced metabolic syndrome rat model

Central obesity and insulin resistance are associated with metabolic syndrome (MetS) which is aggravated by diet and sedentary lifestyle. Athrixia phylicoides (AP) is reported by rural communities to have medicinal benefits associated with MetS such as obesity and type 2 diabetes.

Product: Rat Free fatty acids (FFA) ELISA Kit

Pub Date:2021-11-29   IF: 3.470

Effects of HIF-1α agonist or inhibitor on intestinal mucosal permeability in rats with sepsis

Objective To investigate the effects of sepsis and HIF-1α agonist or inhibitor on intestinal mucosal barrier function.Methods SD rats were randomly divided into sham operation group (sham), Sepsis group treating with cecal ligation and perforation (CLP), Sepsis+HIF-1α agonist group (sepsis + DMOG) receiving intraperitoneal injection of HIF-1α agonist DMOG (40 mg/kg) for 7 consecutive days before CLP, Sepsis+HIF-1α inhibitor group (sepsis+BAY87-2243) orally administered with HIF-1α inhibitor BAY87-2243 (9 mg/kg) for 3 consecutive days before CLP.

Product: Rat D-lactic acid ELISA Kit

Pub Date:2021-10-27   IF: 0.552

Serum Mitochondrial Quality Control Related Biomarker Levels are Associated with Organ Dysfunction in Septic Patients

To investigate the feasibility and the value of using mitochondrial quality control (MQC)-related proteins as biomarkers in septic patients.The enrolled subjects were divided into four groups: healthy control group (n = 30), intensive care unit (ICU) control group (n = 62), septic nonshock group (n = 40), and septic shock group (n = 94). Serum levels of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), fission protein 1 (Fis1), mitofusin2 (Mfn2), and Parkin were measured by enzyme-linked immunosorbent assay at the time of enrollment for all groups. Clinical parameters and laboratory test results were also collected.

Product: Human Mitochondrial fission 1 protein (FIS1) ELISA Kit  Human Mitofusin-2 (MFN2) ELISA Kit 

Pub Date:2021-09-01   IF: 3.454

Comprehensive Analysis of DOK Family Genes Expression, Immune Characteristics, and Drug Sensitivity in Human Tumors

DOK is a new type of regulatory protein family that participates in the regulation of tumor cell growth. However, most of the studies are conducted in cell lines, and systematic studies have not been conducted in human tumors.

Product: Rabbit Anti-Human Dok-1 Polyclonal Antibody  Rabbit Anti-Human Dok-2 Polyclonal Antibody  Rabbit Anti-Human Dok-4 Polyclonal Antibody  Rabbit Anti-Human Dok-6 Polyclonal Antibody 

Pub Date:2021-06-12   IF: 6.992

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