2017-06-02
Interleukin 6 (IL-6) is an important part of cytokines families, in the central position of acute inflammation and acute response. It can regulate hepar through stimulating production the production of CRP and fibrinogen. Many infectious diseases can result in higher serum level of IL-6, and IL-6 level is closely related to the prognosis of patients.
IL-6 is a kind of inflammatory factor, as well as pleiotropic cytokine with wide range of functions. It is secreted by T cells, B cells, mononuclear macrophages and endothelial cells after the bodys inflammatory stimulation. As the key component of inflammation medium network, IL-6 is the first responding cell factor which will induces the generation of CRP and PCT while Inflammation happens. Both of them can be generated rapidly in the case of infection, internal and external injury, surgery, stress reaction, brain death, cancer and other conditions of acute inflammation. IL-6 participates in the happens and development of many diseases. Its change in inflammation,viral infections, autoimmune diseases is earlier than CRT. Research shows that IL-6 level will grow rapidly after bacterial infection. PCT starts rapid growth within 2 hours, and CRP is after 6 hours. Secretion of IL-6 or abnormal gene expression often reults in series of disease. In pathological conditions, IL-6 can be secreted into the blood circulation. Detection of IL-6 plays an important role of disease understanding and prognosis.
IL-6 clinical significance
reference range
| clinical application |
<7 pg/mL | Normal |
7-150 pg/mL | Mild inflammation or slight infection |
150-250 pg/mL | General bacterial infections or systemic inflammatory response |
>250 pg/mL | May be sepsis |
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