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Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients withmyeloproliferative neoplasms
While scientists from University of Pavia found that in CALR-mutated MPNs, defective interaction between mutant calreticulin and SOCE proteins promotes megakaryocyte proliferation. Their research has been published in Blood recently.
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08
Nov,2019
Scientists identify genetic variation linked to severity of ALS
A discovery made several years ago in a lab researching asthma at Wake Forest School of Medicine may now have implications for the treatment of amyotrophic lateral sclerosis (ALS), a disease with no known cure and only two FDA-approved drugs to treat its progression and severity.
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18
Oct,2019
Improving research with more effective antibodies
A new study points to the need for better antibody validation, and outlines a process that other labs can use to make sure the antibodies they work with function properly.
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18
Oct,2019
Nuclear S-Nitrosylation Defines an Optimal Zone for Inducing Pluripotency
Scientists from Houston Methodist Research Institute released their research of Nuclear S-Nitrosylations on Circulation.They found that cell-autonomous innate immune signaling causes global changes in the expression of epigenetic modifiers to facilitate nuclear reprogramming to pluripotency.
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15
Oct,2019
JAK2 mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms
In September, scientists from University Hospital Basel, Basel, Ba, Switzerland published their study of mutant JAK2 in Blood. Mutant JAK2 induces a hitherto unrecognized metabolic phenotype, consisting of hypoglycemia, adipose tissue atrophy and early mortality.
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14
Oct,2019
ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS
Recently scientists from German Center for Neurodegenerative Diseases (DZNE) published their big discovery on Neuron.The severing activity of ADF/cofilin is critical for axon regeneration. Injured axons fail to regenerate in the adult CNS, which contrasts with their vigorous growth during embryonic development.
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17
Sep,2019
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